Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Por um escritor misterioso
Descrição
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://pubs.acs.org/cms/10.1021/acs.jmedchem.1c00789/asset/images/medium/jm1c00789_0015.gif)
Discovery of M-1121 as an Orally Active Covalent Inhibitor of
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41375-021-01309-y/MediaObjects/41375_2021_1309_Fig4_HTML.png)
Therapeutic implications of menin inhibition in acute leukemias
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://ars.els-cdn.com/content/image/1-s2.0-S0006497120820023-grabsf1.jpg)
Synergistic targeting of FLT3 mutations in AML via combined menin
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.mdpi.com/molecules/molecules-28-03026/article_deploy/html/images/molecules-28-03026-g002.png)
Molecules, Free Full-Text
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13148-019-0723-0/MediaObjects/13148_2019_723_Fig1_HTML.png)
Co-inhibition of HDAC and MLL-menin interaction targets MLL
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.biorxiv.org/content/biorxiv/early/2021/12/13/2021.10.22.465184/F5.large.jpg)
Molecular switch between mammalian MLL complexes dictates response
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://europepmc.org/articles/PMC4138051/bin/nihms602476f1.jpg)
Challenges and opportunities in targeting the menin-MLL
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.researchgate.net/profile/Shihan-He/publication/230769410/figure/fig6/AS:393319688491014@1470786129284/MI-2-2-exhibits-pronounced-activity-in-MV411-human-leukemia-cells-with-MLL-AF4_Q320.jpg)
MI-2-2 exhibits pronounced activity in MV4;11 human leukemia cells
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.biorxiv.org/content/biorxiv/early/2022/04/13/2021.10.22.465184/F25.medium.gif)
A molecular switch between mammalian MLL complexes dictates
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://pubs.rsc.org/image/article/2017/MD/c7md00170c/c7md00170c-f2_hi-res.gif)
Theoretical models of inhibitory activity for inhibitors of
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fleu.2015.144/MediaObjects/41375_2016_Article_BFleu2015144_Fig1_HTML.jpg)
Menin-MLL inhibitors block oncogenic transformation by MLL-fusion
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://files.rcsb.org/pub/pdb/validation_reports/gq/4gq6/4gq6_multipercentile_validation.png)
RCSB PDB - 4GQ6: Human menin in complex with MLL peptide
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.ncbi.nlm.nih.gov/books/NBK133428/bin/ml227fu2.jpg)
Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.frontiersin.org/files/Articles/240371/fped-05-00004-HTML-r1/image_m/fped-05-00004-g001.jpg)
Frontiers MLL-Rearranged Leukemias—An Update on Science and
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.future-science.com/cms/10.4155/fmc.13.214/asset/images/medium/figure6.gif)
Challenges and opportunities in targeting the menin–MLL
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